Hannover Medical School
Institute of Clinical Pharmacology
Carl-Neuberg-Str. 1
30625 Hannover

Germany

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Project Leader

Prof. Dr. med. Jens Jordan Project Leader  Phone: +49-(0)511 532 2821  Fax: +49-(0)511 532 2750  Contact

Project Staff

PD Dr. med. Dipl.-Biol. Stefan Engeli Group Leader  Phone: +49-(0)511 532 2796  Fax: +49-(0)511 532 2750  Contact

Bibiana Beckmann Technician (Cell and Molecular Biology)

Institute Presentation

Jens Jordan is Director of the Institute of Clinical Pharmacology, Hannover Medical School, Germany, since April 2008. He published more than 100 original contributions in peer reviewed journals. His research focuses on metabolic and cardiovascular regulation and mechanisms of obesity-associated cardiovascular disease in human subjects. Prof. Jordan was founder of the Franz-Volhard-Clinical Research Center at the University Clinic Charité in Berlin, which was one of the leading facilities for metabolic and cardiovascular patient oriented research in Germany. At the Hannover Medical School, he is now heading a fully equipped academic clinical research center. Furthermore, the institute has a strong background in biomarker and drug analysis (HPLC, GC-MS/MS; LC-MS/MS) with a focus on oxidative stress, NO metabolism, prostaglandins, and endocannabinoids. The laboratory of adipocyte and skeletal muscle physiology is supervised by Dr. Engeli. He has a longstanding experience in characterizing human adipose tissue samples from clinical studies (more than 30 original contributions in peer reviewed journals). Substantial research on the lipolytic effects of the atrial natriuretic peptide in vivo was performed by Prof. Jordan and his co-workers. Prof. Jordan and Dr. Engeli participate in the ADAPT consortium (HEALTH-F2-2008-201100) which focuses on adipokine research. Their contribution is on epicardial adipose tissue in relationship to cardiac function and adipokine production in obese subjects. In this study, cardiac MRI is combined with MRI imaging and spectroscopy of adipose tissue, liver, and skeletal muscle in >180 obese women and men (cross-sectional study) and >90 obese women and men after weight loss (longitudinal study for 1 year). These data will also contribute to the understanding of heart function as addressed in the SICA-HF consortium.